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Article

A gene profiling deconvolution approach to estimating immune cell composition from complex tissues.

BMC bioinformatics - 8 May 2018

Chen Shu-Hwa, Kuo Wen-Yu, Su Sheng-Yao, Chung Wei-Chun, Ho Jen-Ming, Lu Henry Horng-Shing, Lin Chung-Yen

Abstract excerpt

BACKGROUND: A new emerged cancer treatment utilizes intrinsic immune surveillance mechanism that is silenced by those malicious cells. Hence, studies of tumor infiltrating lymphocyte populations (TILs) are key to the success of advanced treatments. In addition to laboratory methods such as immunohistochemistry and flow cytometry, in silico gene expression deconvolution methods are available for analyses of...

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Identifiers

PMID: 29745829
DOI: 10.1186/s12859-018-2069-6
PMCID: PMC5998872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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