Article
Next-generation sequencing informs diagnosis and identifies unexpected therapeutic targets in lung squamous cell carcinomas.
Lung cancer (Amsterdam, Netherlands) - 1 Feb 2020
Sands Jacob M, Nguyen Tom, Shivdasani Priyanka, Sacher Adrian G, Cheng Michael L, Alden Ryan S, Jänne Pasi A, Kuo Frank C, Oxnard Geoffrey R, Sholl Lynette M
Abstract excerpt
OBJECTIVES: Potentially targetable genomic alterations have been identified in lung squamous cell carcinoma (LUSC), but none have yet translated into effective therapy. We examined potential benefits of next generation sequencing (NGS) in a cohort of consecutive LUSC patients with emphasis on distinctions between smokers and light/never smokers and implications for clinical trial enrollment. METHODS: We...
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