Article
Comprehensive molecular profiling of squamous non-small cell lung cancer reveals high incidence of actionable genomic alterations among patients with no history of smoking.
Lung cancer (Amsterdam, Netherlands) - 1 Feb 2025
Reuss Joshua E, Zaemes Jacob, Gandhi Nishant, Walker Phillip, Patel Sandip P, Xiu Joanne, Aggarwal Charu, Vanderwalde Ari, Ramalingam Suresh S, Halmos Balazs, Liu Stephen V
Abstract excerpt
BACKGROUND: Next-generation sequencing (NGS) to detect actionable genomic driver alterations (AGAs) is critical to appropriate management of non-small cell lung cancer (NSCLC), but is inconsistently performed for squamous NSCLC (sqNSCLC). Molecular characterization of sqNSCLC by smoking status has not been well-reported. We analyzed a large cohort of sqNSCLC utilizing NGS to elucidate molecular differences in...
Topics
- Humans
- Lung Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Male
- Female
- Middle Aged
- Mutation
- Aged
- High-Throughput Nucleotide Sequencing
- Smoking
- Biomarkers, Tumor
- Genomics
- Carcinoma, Squamous Cell