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Article

Genetic changes in squamous cell lung cancer: a review.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 May 2012

Heist Rebecca S, Sequist Lecia V, Engelman Jeffrey A

Abstract excerpt

Identifying specific somatic mutations that drive tumor growth has transformed the treatment of lung cancer. For example, cancers with sensitizing epidermal growth factor receptor mutations and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase translocations can have remarkable responses to epidermal growth factor receptor and ALK inhibitors respectively, leading to significant clinical...

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Source

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Identifiers

PMID: 22722794
DOI: 10.1097/JTO.0b013e31824cc334
PMCID: PMC3404741

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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