Article
Clinical next-generation sequencing in patients with non-small cell lung cancer.
Cancer - 15 Feb 2015
Hagemann Ian S, Devarakonda Siddhartha, Lockwood Christina M, Spencer David H, Guebert Kalin, Bredemeyer Andrew J, Al-Kateb Hussam, Nguyen TuDung T, Duncavage Eric J, Cottrell Catherine E, Kulkarni Shashikant, Nagarajan Rakesh, Seibert Karen, Baggstrom Maria, Waqar Saiama N, Pfeifer John D, Morgensztern Daniel, Govindan Ramaswamy
Abstract excerpt
BACKGROUND: A clinical assay was implemented to perform next-generation sequencing (NGS) of genes commonly mutated in multiple cancer types. This report describes the feasibility and diagnostic yield of this assay in 381 consecutive patients with non-small cell lung cancer (NSCLC). METHODS: Clinical targeted sequencing of 23 genes was performed with DNA from formalin-fixed, paraffin-embedded (FFPE) tumor tissue....
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