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Clinical Utility of Next-Generation Sequencing in Tumors Diagnosed as Lung Squamous Cell Carcinoma: Real-World Data of Diagnostic and Therapeutic Implications.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2026

Odintsov Igor, Siegmund Stephanie E, Pecci Federica, Ricciuti Biagio, LoPiccolo Jaclyn, Sands Jacob M, Wang Charlotte I, Sholl Lynette M, Dong Fei

Abstract excerpt

Lung squamous cell carcinoma (LUSC) is the second most common subtype of non-small cell lung carcinoma (NSCLC), typically associated with a poor prognosis. Unlike lung adenocarcinoma, the application of next-generation sequencing (NGS) in LUSC has lagged because of the long-standing perception of low therapeutic yield, primarily based on highly selected, resected cohorts. We sought to determine the real-world...

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Identifiers

PMID: 41786210
DOI: 10.1016/j.modpat.2026.100985

Genes

ALK
EGFR
KRAS
MET
ROS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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