Single-center experience using reflex-targeted next-generation sequencing at diagnosis of squamous cell lung carcinoma in daily practice.

doi:10.1007/s00428-025-04147-w

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Article

Single-center experience using reflex-targeted next-generation sequencing at diagnosis of squamous cell lung carcinoma in daily practice.

Virchows Archiv : an international journal of pathology - 1 Apr 2026

Pirlog Radu, Hofman Véronique, Goffinet Samantha, Bontoux Christophe, Lespinet Virginie, Rignol Guylène, Bordone Olivier, Lacoux Caroline, Tanga Virginie, Bonnetaud Christelle, Lassalle Sandra, Long-Mira Elodie, Lim Davy, Berthet Jean Philippe, Benzaquen Jonathan, Boutros Jacques, Marquette Charles, Heeke Simon, Ilié Marius, Hofman Paul

Abstract excerpt

Patients with lung squamous cell carcinoma (LSCC) rarely benefit from targeted therapies in daily practice. Current and future clinical trials targeting genomic alterations may open up promising therapeutic strategies for this population. We evaluated the usefulness and the clinical added value in the real world of the analysis of LSCC at diagnosis using reflex-targeted next-generation sequencing (NGS) on-site in...

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PMID: 40608133
DOI: 10.1007/s00428-025-04147-w

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EGFR
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KRAS
PIK3CA
PTEN
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