Article
Mutation profiles in early-stage lung squamous cell carcinoma with clinical follow-up and correlation with markers of immune function.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jan 2017
Choi M, Kadara H, Zhang J, Parra E R, Rodriguez-Canales J, Gaffney S G, Zhao Z, Behrens C, Fujimoto J, Chow C, Kim K, Kalhor N, Moran C, Rimm D, Swisher S, Gibbons D L, Heymach J, Kaftan E, Townsend J P, Lynch T J, Schlessinger J, Lee J, Lifton R P, Herbst R S, Wistuba I I
Abstract excerpt
Background: Lung squamous cell carcinoma (LUSC) accounts for 20–30% of non-small cell lung cancers (NSCLCs). There are limited treatment strategies for LUSC in part due to our inadequate understanding of the molecular underpinnings of the disease. We performed whole-exome sequencing (WES) and comprehensive immune profiling of a unique set of clinically annotated early-stage LUSCs to increase our understanding of...
Topics
- Biomarkers, Tumor
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Cohort Studies
- Follow-Up Studies
- Humans
- Immunohistochemistry
- Immunophenotyping