Article
Illegitimate WNT pathway activation by beta-catenin mutation or autocrine stimulation in T-cell malignancies.
Cancer research - 1 Sept 2008
Groen Richard W J, Oud Monique E C M, Schilder-Tol Esther J M, Overdijk Marije B, ten Berge Derk, Nusse Roel, Spaargaren Marcel, Pals Steven T
Abstract excerpt
Recent studies in mice have shown a role for the canonical WNT pathway in lymphocyte development. Because cancers often arise as a result of aberrant activation of signaling cascades that normally promote the self-renewal and expansion of their progenitor cells, we hypothesized that activation of the WNT pathway might contribute to the pathogenesis of lymphoproliferative disease. Therefore, we screened a large...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.