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Article

Molecular evolution and functional divergence of tubulin superfamily in the fungal tree of life.

Scientific reports - 23 Oct 2014

Zhao Zhongtao, Liu Huiquan, Luo Yongping, Zhou Shanyue, An Lin, Wang Chenfang, Jin Qiaojun, Zhou Mingguo, Xu Jin-Rong

Abstract excerpt

Microtubules are essential for various cellular activities and β-tubulins are the target of benzimidazole fungicides. However, the evolution and molecular mechanisms driving functional diversification in fungal tubulins are not clear. In this study, we systematically identified tubulin genes from 59 representative fungi across the fungal kingdom. Phylogenetic analysis showed that α-/β-tubulin genes underwent...

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Identifiers

PMID: 25339375
DOI: 10.1038/srep06746
PMCID: PMC5381371

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