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Article

Functional significance may underlie the taxonomic utility of single amino acid substitutions in conserved proteins.

Journal of molecular evolution - 1 Apr 2010

Tyler Kevin M, Wagner Gerd K, Wu Qiong, Huber Katharina T

Abstract excerpt

We hypothesized that some amino acid substitutions in conserved proteins that are strongly fixed by critical functional roles would show lineage-specific distributions. As an example of an archetypal conserved eukaryotic protein we considered the active site of beta-tubulin. Our analysis identified one amino acid substitution--beta-tubulin F224--which was highly lineage specific. Investigation of beta-tubulin for...

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Identifiers

PMID: 20386893
DOI: 10.1007/s00239-010-9338-y
PMCID: PMC2874023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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