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Article

Sprouty4 correlates with favorable prognosis in perihilar cholangiocarcinoma by blocking the FGFR-ERK signaling pathway and arresting the cell cycle

22 Nov 2019

Abstract excerpt

BACKGROUND: Perihilar cholangiocarcinoma (PHCC) is the most common subtype of cholangiocarcinoma(CCA). We previously investigated the expression pattern of Sprouty(SPRY) in intrahepatic cholangiocarcinoma(ICC), but the expression and clinical significance of SPRY family members in PHCC are still unknown. METHODS: The expression of SPRY family members(SPRY1-4) was detected in different subtypes of CCA and...

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PMID: 31761616
DOI: 10.1016/j.ebiom.2019.11.021

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