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Article

H3F3A K27M mutation in pediatric CNS tumors: a marker for diffuse high-grade astrocytomas.

American journal of clinical pathology - 1 Mar 2013

Gielen Gerrit H, Gessi Marco, Hammes Jennifer, Kramm Christof M, Waha Andreas, Pietsch Torsten

Abstract excerpt

Brain tumors are one of the most common childhood malignancies. Diffuse high-grade gliomas represent approximately 10% of pediatric brain tumors. Exon sequencing has identified a mutation in K27M of the histone H3.3 gene (H3F3A K27M and G34R/V) in about 20% of pediatric glioblastomas, but it remains to be seen whether these mutations can be considered specific for pediatric diffuse high-grade astrocytomas or also...

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PMID: 23429371
DOI: 10.1309/AJCPABOHBC33FVMO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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