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Article

IgG and Fc Receptor Genetic Variation Associates With Functional Antibody Responses in a DNA and Protein Candidate HIV Vaccine Trial.

Journal of acquired immune deficiency syndromes (1999) - 1 Dec 2025

Conley Haleigh E, Oh Song Young, Garrett Nigel, Kublin James, Monaco Cynthia L, Watts Spencer, Jha Shalini, Ferrari Guido, Tomaras Georgia D, Geraghty Daniel E, Chan Cliburn, Pollara Justin

Abstract excerpt

BACKGROUND: The HVTN108 trial evaluated the safety and immunogenicity of a DNA prime, adjuvanted protein boost HIV vaccine in the United States and South Africa. The underlying factors influencing individual variation in vaccine responsiveness are unknown. In this study, we defined the IgG Fc and Fc receptor (FcR) genotypes in the HVTN108 cohort to test our hypothesis that IgG and FcR genetic variation can affect...

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Topics

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Share to AIDS Vaccines
Share to Antibody-Dependent Cell Cytotoxicity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibody Formation

Share to HIV Antibodies

Share to Immunoglobulin G

Share to Receptors, Fc

Share to South Africa

Share to Vaccines, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 40704585
DOI: 10.1097/QAI.0000000000003734
PMCID: PMC12818096

Genes

FCER1A
FCER2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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