Article
Meiotic crossover number and distribution are regulated by a dosage compensation protein that resembles a condensin subunit.
Genes & development - 15 Jan 2008
Tsai Chun J, Mets David G, Albrecht Michael R, Nix Paola, Chan Annette, Meyer Barbara J
Abstract excerpt
Biological processes that function chromosome-wide are not well understood. Here, we show that the Caenorhabditis elegans protein DPY-28 controls two such processes, X-chromosome dosage compensation in somatic cells and meiotic crossover number and distribution in germ cells. DPY-28 resembles a subunit of condensin, a conserved complex required for chromosome compaction and segregation. In the soma, DPY-28...
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