Article
Cellular senescence and senescence-associated T cells as a potential therapeutic target.
Geriatrics & gerontology international - 1 Feb 2020
Nakagami Hironori
Abstract excerpt
More than 50 years ago, Hayflick et al. found that no long-lived, proliferative cells remained in long-term cell culture experiments; this phenomenon is called "cellular senescence." This finding has allowed us to understand basic individual tissue aging and cancer inhibition from the view of cellular aging. Senescent cells survive and accumulate in the body, and secrete various inflammatory cytokines or...
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