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Senescence and aging: Causes, consequences, and therapeutic avenues

7 Nov 2017

Abstract excerpt

Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. Although we are far from understanding the biological basis of aging, research suggests that targeting the aging process itself could ameliorate many age-related pathologies. Senescence is a cellular response characterized by a stable growth arrest and other phenotypic alterations that include a...

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PMID: 29114066
DOI: 10.1083/jcb.201708092

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