Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Upregulation of Cisd2 attenuates Alzheimer's‐related neuronal loss in mice

14 Dec 2019

Abstract excerpt

CDGSH iron-sulfur domain-containing protein 2 (Cisd2), a protein that declines in an age-dependent manner, mediates lifespan in mammals. Cisd2 deficiency causes accelerated aging and shortened lifespan, whereas persistent expression of Cisd2 promotes longevity in mice. Alzheimer's disease (AD) is the most prevalent form of senile dementia and is without an effective therapeutic strategy. We investigated whether...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Epigenetics and DNA Methylation
Share to Neurological diseases and metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31837018
DOI: 10.1002/path.5374

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Upregulation of Cisd2 attenuates Alzheimer's‐related neuronal loss in micePMID 31837018Read ↗

Sequence variants of the aging gene CISD2 and the risk for Alzheimer's disease.Semantic proximity Read ↗

A persistent level of Cisd2 extends healthy lifespan and delays aging in miceSemantic proximity Read ↗

CD2AP deficiency aggravates Alzheimer's disease phenotypes and pathology through p38 MAPK activation.Semantic proximity Read ↗

Mitochondrial complex I deficiency induces Alzheimer's disease–like signatures that are reversible by targeted therapySemantic proximity Read ↗

Alzheimer's disease risk gene CD2AP is a dose-sensitive determinant of synaptic structure and plasticity.Semantic proximity Read ↗

Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesisSemantic proximity Read ↗

ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegenerationSemantic proximity Read ↗

Metformin promotes broad neuroprotection and proteostatic resilience via rngo/DDI2 stabilisationSemantic proximity Read ↗

Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged miceSemantic proximity Read ↗

Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture.Semantic proximity Read ↗

cindr, the Drosophila Homolog of the CD2AP Alzheimer’s Disease Risk Gene, Is Required for Synaptic Transmission and ProteostasisSemantic proximity Read ↗

Brain Dicer1 is down-regulated in a mouse model of Alzheimer’s disease via Aβ42-induced repression of nuclear factor erythroid 2-related factor 2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.