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Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice

24 Jul 2022

Abstract excerpt

BACKGROUND: The human CISD2 gene is located within a longevity region mapped on chromosome 4q. In mice, Cisd2 levels decrease during natural aging and genetic studies have shown that a high level of Cisd2 prolongs mouse lifespan and healthspan. Here, we evaluate the feasibility of using a Cisd2 activator as an effective way of delaying aging. METHODS: Hesperetin was identified as a promising Cisd2 activator by...

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PMID: 35871686
DOI: 10.1186/s12929-022-00838-7

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