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Article

Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice.

The Journal of experimental medicine - 9 Feb 2015

Dong Yingying, Geng Yan, Li Lian, Li Xiaohe, Yan Xiaohua, Fang Yinshan, Li Xinxin, Dong Siyuan, Liu Xue, Li Xue, Yang Xiuhong, Zheng Xiaohong, Xie Ting, Liang Jiurong, Dai Huaping, Liu Xinqi, Yin Zhinan, Noble Paul W, Jiang Dianhua, Ning Wen

Abstract excerpt

Progressive tissue fibrosis is a cause of major morbidity and mortality. Pulmonary fibrosis is an epithelial-mesenchymal disorder in which TGF-β1 plays a central role in pathogenesis. Here we show that follistatin-like 1 (FSTL1) differentially regulates TGF-β and bone morphogenetic protein signaling, leading to epithelial injury and fibroblast activation. Haplodeletion of Fstl1 in mice or blockage of FSTL1 with a...

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Share to Antibiotics, Antineoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25584011
DOI: 10.1084/jem.20121878
PMCID: PMC4322044

Genes

FSTL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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