Article
Deletion of Serpina1a, a murine α1-antitrypsin ortholog, results in embryonic lethality.
Experimental lung research - 1 Jun 2011
Wang Dongmei, Wang Weimin, Dawkins Paul, Paterson Trevor, Kalsheker Noor, Sallenave Jean-Michel, Houghton A McGarry
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States Approximately 1% to 2% of COPD patients suffer from α(1)-antitrypsin (A1AT) deficiency, the major inheritable predisposition to COPD/emphysema. To further study the role of A1AT deficiency in the pathogenesis of COPD/emphysema, the authors attempted to generate null-mutant mice for Serpina1a, 1 of 2 A1AT...
Topics
- Animal Structures
- Animals
- Embryo Loss
- Embryonic Development
- Female
- Gene Duplication
- Genetic Predisposition to Disease
- Humans
- Male
- Mice
- Pulmonary Disease, Chronic Obstructive