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Article

Apical Secretion of FSTL1 in the Respiratory Epithelium for Normal Lung Development.

PloS one - 1 Jan 2016

Li Xiaohe, Fang Yinshan, Li Xue, Liang Jiurong, Jiang Dianhua, Geng Yan, Ning Wen

Abstract excerpt

Follistatin-like 1 (FSTL1) is a secreted bone morphogenetic protein (BMP) antagonist, and it plays a crucial role in normal lung development. Deletion of Fstl1 leads to postnatal death in mice due to respiratory failure. To further explore the role of FSTL1 in mouse lung development, we created a transgene SFTPC-Fstl1 allele mouse displaying significant epithelial overexpression of Fstl1 in all stages of lung...

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Share to Bone Morphogenetic Protein 4
Share to Bronchoalveolar Lavage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27355685
DOI: 10.1371/journal.pone.0158385
PMCID: PMC4927184

Genes

FSTL1
SFTPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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