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Article

Decrease of FSTL1-BMP4-Smad signaling predicts poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma.

Scientific reports - 29 Aug 2017

Chiou Jean, Su Chia-Yi, Jan Yi-Hua, Yang Chih-Jen, Huang Ming-Shyan, Yu Yung-Luen, Hsiao Michael

Abstract excerpt

Follistatin-related protein 1 (FSTL1) plays a critical role in lung development through regulating BMP4-p-Smad1/5/8-Smad4 pathway. Regarding that many developmental pathways in embryogenesis are dysregulated in cancer, we aim to unravel the role of FSTL1-BMP4-Smad pathway in lung cancer. Our results showed low FSTL1 immunoexpression was significantly correlated with poor prognosis while patients with low BMP4 or...

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Topics

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Share to Adenocarcinoma of Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

Share to Kaplan-Meier Estimate

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Share to Proto-Oncogene Proteins p21(ras)

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Source

Open in PubMed Open full text

Identifiers

PMID: 28852126
DOI: 10.1038/s41598-017-10366-2
PMCID: PMC5575295

Genes

FSTL1
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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