Article
Deletion of Fstl1 (Follistatin-Like 1) From the Endocardial/Endothelial Lineage Causes Mitral Valve Disease.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2017
Prakash Stuti, Borreguero Luis J J, Sylva Marc, Flores Ruiz Lorena, Rezai Fereshte, Gunst Quinn D, de la Pompa José-Luis, Ruijter Jan M, van den Hoff Maurice J B
Abstract excerpt
OBJECTIVE: Fstl1 (Follistatin-like 1) is a secreted protein that is expressed in the atrioventricular valves throughout embryonic development, postnatal maturation, and adulthood. In this study, we investigated the loss of Fstl1 in the endocardium/endothelium and their derived cells. APPROACH AND RESULTS: We conditionally ablated Fstl1 from the endocardial lineage using a transgenic Tie2-Cre mouse model. These...
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