Article
Targeted regulation of fibroblast state by CRISPR-mediated CEBPA expression.
Respiratory research - 11 Dec 2019
Liu Wei, Meridew Jeffrey A, Aravamudhan Aja, Ligresti Giovanni, Tschumperlin Daniel J, Tan Qi
Abstract excerpt
BACKGROUND: Fibroblasts regulate tissue homeostasis and the balance between tissue repair and fibrosis. CCAAT/enhancer-binding protein alpha (CEBPA) is a key transcription factor that regulates adipogenesis. CEBPA has been shown to be essential for lung maturation, and deficiency of CEBPA expression leads to abnormal lung architecture. However, its specific role in lung fibroblast regulation and fibrosis has not...
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