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Article

A Novel Fibroblast Reporter Cell Line for in vitro Studies of Pulmonary Fibrosis

9 Oct 2020

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a fatal disease of the lower respiratory tract with restricted therapeutic options. Repetitive injury of the bronchoalveolar epithelium leads to activation of pulmonary fibroblasts, differentiation into myofibroblasts and excessive extracellular matrix (ECM) deposition resulting in aberrant wound repair. However, detailed molecular and cellular mechanisms underlying...

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Identifiers

PMID: 33162897
DOI: 10.3389/fphys.2020.567675

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