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Pathway engineering in yeast for synthesizing the complex polyketide bikaverin

3 Dec 2020

Abstract excerpt

Fungal polyketides display remarkable structural diversity and bioactivity, and therefore the biosynthesis and engineering of this large class of molecules is therapeutically significant. Here, we successfully recode, construct and characterize the biosynthetic pathway of bikaverin, a tetracyclic polyketide with antibiotic, antifungal and anticancer properties, in S. cerevisiae. We use a green fluorescent protein...

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PMID: 33273470
DOI: 10.1038/s41467-020-19984-3

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