Article
Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate.
Human molecular genetics - 15 Jul 2008
Chiquet Brett T, Blanton Susan H, Burt Amber, Ma Deqiong, Stal Samuel, Mulliken John B, Hecht Jacqueline T
Abstract excerpt
Non-syndromic cleft lip with or without cleft palate (NSCLP) is a common birth defect. Genetic and environmental factors have been causally implicated and studies have begun to delineate genetic contributions. The Wnt genes are involved in regulating mid-face development and upper lip fusion and are therefore strong candidates for an etiological role in NSCLP. Furthermore, the clf1 region in A/WyN clefting...
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