Article
Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate.
Birth defects research. Part A, Clinical and molecular teratology - 1 Sept 2010
Nikopensius Tiit, Jagomägi Triin, Krjutskov Kaarel, Tammekivi Veronika, Saag Mare, Prane Inga, Piekuse Linda, Akota Ilze, Barkane Biruta, Krumina Astrida, Ambrozaityte Laima, Matuleviciene Ausra, Kucinskiene Zita Ausrele, Lace Baiba, Kucinskas Vaidutis, Metspalu Andres
Abstract excerpt
BACKGROUND: Orofacial clefts are among the most common birth defects with a strong genetic component. Nonsyndromic cleft palate (NSCP) is a complex malformation determined by the interaction between multiple genes and environmental risk factors. METHODS: We conducted a case-control association study to investigate the role of 40 candidate genes in predisposition to orofacial clefting. Five hundred ninety-one...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.