Article
A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis.
Developmental cell - 18 Oct 2011
Ferretti Elisabetta, Li Bingsi, Zewdu Rediet, Wells Victoria, Hebert Jean M, Karner Courtney, Anderson Matthew J, Williams Trevor, Dixon Jill, Dixon Michael J, Depew Michael J, Selleri Licia
Abstract excerpt
Morphogenesis of mammalian facial processes requires coordination of cellular proliferation, migration, and apoptosis to develop intricate features. Cleft lip and/or palate (CL/P), the most frequent human craniofacial birth defect, can be caused by perturbation of any of these programs. Mutations of WNT, P63, and IRF6 yield CL/P in humans and mice; however, how these genes are regulated remains elusive. We...
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