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Article

Advances in genetic mechanisms and precision medicine research for cleft lip and palate.

Gene - 20 Apr 2026

Yu Zhong, Feng Chenhui, Li Tianhua, Duan Han, Zhang Haofuzi

Abstract excerpt

Cleft Lip and Palate (CL/P) is the most common congenital craniofacial malformation. However, a central challenge remains in understanding how this multi-layered, dynamically interactive gene network is precisely modulated across specific cell lineages and developmental time windows, and how environmental factors integrate with genetic susceptibilities to drive phenotypic outcomes. Its etiology originates from an...

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Source

Identifiers

PMID: 41687982
DOI: 10.1016/j.gene.2026.150045

Genes

GRHL3
MSX1
PAX9
SATB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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