Article
IRF6 gene variants in Central European patients with non-syndromic cleft lip with or without cleft palate.
European journal of oral sciences - 1 Dec 2009
Birnbaum Stefanie, Ludwig Kerstin U, Reutter Heiko, Herms Stefan, de Assis Nilma A, Diaz-Lacava Amalia, Barth Sandra, Lauster Carola, Schmidt Gül, Scheer Martin, Saffar Mitra, Martini Markus, Reich Rudolf H, Schiefke Franziska, Hemprich Alexander, Pötzsch Simone, Pötzsch Bernd, Wienker Thomas F, Hoffmann Per, Knapp Michael, Kramer Franz-Josef, Nöthen Markus M, Mangold Elisabeth
Abstract excerpt
Variants in the interferon regulatory factor 6 (IRF6) gene have repeatedly been associated with non-syndromic cleft lip with or without cleft palate (NSCL/P). A recent study has suggested that the functionally relevant variant rs642961 is the underlying cause of the observed associations. We genotyped rs642961 in our Central European case-control sample of 460 NSCL/P patients and 952 controls. In order to...
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