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Article

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain.

Neurobiology of disease - 1 Apr 2007

Van Raamsdonk Jeremy M, Metzler Martina, Slow Elizabeth, Pearson Jacqueline, Schwab Claudia, Carroll Jeffrey, Graham Rona K, Leavitt Blair R, Hayden Michael R

Abstract excerpt

The YAC128 mouse model of Huntington disease (HD) exhibits motor abnormalities, cognitive dysfunction and selective neuropathology which are similar to the human disease. Backcrossing YAC128 mice from the FVB/N strain onto the C57BL/6 strain and the 129 strain revealed that striatal volume loss and motor dysfunction are penetrant on all three genetic backgrounds. The severity of HD-like phenotypes in these mice...

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Identifiers

PMID: 17276692
DOI: 10.1016/j.nbd.2006.12.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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