Article
Identifying the functional contribution of the defatty-acylase activity of SIRT6.
Nature chemical biology - 1 Aug 2016
Zhang Xiaoyu, Khan Saba, Jiang Hong, Antonyak Marc A, Chen Xiao, Spiegelman Nicole A, Shrimp Jonathan H, Cerione Richard A, Lin Hening
Abstract excerpt
Mammalian sirtuin 6 (SIRT6) exhibits many pivotal functions and multiple enzymatic activities, but the contribution of each activity to the various functions is unclear. We identified a SIRT6 mutant (G60A) that possesses efficient defatty-acylase activity but has substantially decreased deacetylase activity in vitro and no detectable deacetylase activity in cells. The G60A mutant has a decreased ability to bind...
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