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Article

Aconitase 2 inhibits the proliferation of MCF-7 cells promoting mitochondrial oxidative metabolism and ROS/FoxO1-mediated autophagic response.

British journal of cancer - 1 Jan 2020

Ciccarone Fabio, Di Leo Luca, Lazzarino Giacomo, Maulucci Giuseppe, Di Giacinto Flavio, Tavazzi Barbara, Ciriolo Maria Rosa

Abstract excerpt

BACKGROUND: Deregulation of the tricarboxylic acid cycle (TCA) due to mutations in specific enzymes or defective aerobic metabolism is associated with tumour growth. Aconitase 2 (ACO2) participates in the TCA cycle by converting citrate to isocitrate, but no evident demonstrations of its involvement in cancer metabolism have been provided so far. METHODS: Biochemical assays coupled with molecular biology, in...

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Identifiers

PMID: 31819175
DOI: 10.1038/s41416-019-0641-0
PMCID: PMC7051954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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