Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming

26 Nov 2017

Abstract excerpt

Metabolic reprogramming in breast tumors is linked to increases in putative oncogenic metabolites that may contribute to malignant transformation. We previously showed that accumulation of the oncometabolite, 2-hydroxyglutarate (2HG), in breast tumors was associated with MYC signaling, but not with isocitrate dehydrogenase (IDH) mutations, suggesting a distinct mechanism for increased 2HG in breast cancer. Here,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Diet and metabolism studies
Share to Metabolism, Diabetes, and Cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29202474
DOI: 10.1172/jci93815

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ADHFE1 is a breast cancer oncogene and induces metabolic reprogrammingPMID 29202474Read ↗

Biochemical Background in Mitochondria Affects 2HG Production by IDH2 and ADHFE1 in Breast CarcinomaSemantic proximity Read ↗

Oncogenic role of fumarate hydratase in breast cancer: metabolic reprogramming and mechanistic insightsSemantic proximity Read ↗

2-Hydroxyglutarate in Cancer Cells.Semantic proximity Read ↗

Beyond Isocitrate Dehydrogenase Mutations: Emerging Mechanisms for the Accumulation of the Oncometabolite 2-Hydroxyglutarate.Semantic proximity Read ↗

Wild-type IDH2 is a therapeutic target for triple-negative breast cancer.Semantic proximity Read ↗

Isocitrate dehydrogenase 1 (IDH1) mutation in breast adenocarcinoma is associated with elevated levels of serum and urine 2-hydroxyglutarate.Semantic proximity Read ↗

A joint analysis of metabolomics and genetics of breast cancer.Semantic proximity Read ↗

Codependency of Metabolism and Epigenetics Drives Cancer Progression: A ReviewSemantic proximity Read ↗

Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4Semantic proximity Read ↗

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer.Semantic proximity Read ↗

ADAR1 Regulates Lipid Remodeling to Dictate Ferroptosis SensitivitySemantic proximity Read ↗

Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.