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Article

Genetic alterations in Krebs cycle and its impact on cancer pathogenesis.

Biochimie - 1 Apr 2017

Sajnani Karishma, Islam Farhadul, Smith Robert Anthony, Gopalan Vinod, Lam Alfred King-Yin

Abstract excerpt

Cancer cells exhibit alterations in many cellular processes, including oxygen sensing and energy metabolism. Glycolysis in non-oxygen condition is the main energy production process in cancer rather than mitochondrial respiration as in benign cells. Genetic and epigenetic alterations of Krebs cycle enzymes favour the shift of cancer cells from oxidative phosphorylation to anaerobic glycolysis. Mutations in genes...

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PMID: 28219702
DOI: 10.1016/j.biochi.2017.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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