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Article

Identification of a functional human-unique 351-bp Alu insertion polymorphism associated with major depressive disorder in the 1p31.1 GWAS risk loci.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 2020

Liu Weipeng, Li Wenqiang, Cai Xin, Yang Zhihui, Li Huijuan, Su Xi, Song Meng, Zhou Dong-Sheng, Li Xingxing, Zhang Chen, Shao Minglong, Zhang Luwen, Yang Yongfeng, Zhang Yan, Zhao Jingyuan, Chang Hong, Yao Yong-Gang, Fang Yiru, Lv Luxian, Li Ming, Xiao Xiao

Abstract excerpt

Genome-wide association studies (GWAS) have reported substantial single-nucleotide polymorphisms (SNPs) associated with major depressive disorder (MDD), but the underlying functional variations in the GWAS risk loci are unclear. Here we show that the European MDD genome-wide risk-associated allele of rs12129573 at 1p31.1 is associated with MDD in Han Chinese, and this SNP is in strong linkage disequilibrium (LD)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32193514
DOI: 10.1038/s41386-020-0659-2
PMCID: PMC7235090

Genes

DRD2
FLOT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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