Article
Common variants in CACNA1C and MDD susceptibility: A comprehensive meta-analysis.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2016
Rao Shuquan, Yao Yao, Zheng Chuan, Ryan Joanne, Mao Canquan, Zhang Fuquan, Meyre David, Xu Qi
Abstract excerpt
Major depressive disorder (MDD) is one of the most common psychiatric disorders with a relatively high heritability (35-40%). Though rs1006737 in the CACNA1C gene showed significant association with MDD in a British large-scale candidate association study, most of the replication analyses with relatively small sample size reported negative association. Moreover, this locus has never been identified in previous...
Topics
- Calcium Channels, L-Type
- Depressive Disorder, Major
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Genome-Wide Association Study
- Genotype