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Regulation of the Keratocyte Phenotype and Cell Behavior Derived from Human Induced Pluripotent Stem Cells by Substrate Stiffness.

ACS biomaterials science & engineering - 13 Feb 2023

Zhang Lan, Liang Liying, Su Ting, Guo Yonglong, Yu Quan, Zhu Deliang, Cui Zekai, Zhang Jun, Chen Jiansu

Abstract excerpt

Substrate stiffness has been indicated as an important factor to control stem cell fate, including proliferation and differentiation. To optimize the stiffness for the differentiation process from h-iPSCs (human induced pluripotent stem cells) into h-iCSCs (human corneal stromal cells derived from h-iPSCs) and the phenotypic maintenance of h-iCSCs in vitro, h-iPSCs were cultured on matrigel-coated tissue culture...

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PMID: 36668685
DOI: 10.1021/acsbiomaterials.2c01003

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