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Article

Effect of substrate stiffness on the osteogenic differentiation of bone marrow stem cells and bone-derived cells.

Cell biology international - 1 Jun 2013

Witkowska-Zimny Malgorzata, Walenko Katarzyna, Wrobel Edyta, Mrowka Piotr, Mikulska Agnieszka, Przybylski Jacek

Abstract excerpt

There is a profound dependence of cell behaviour on the stiffness of its microenvironment. To gain a better understanding of the regulation of cellular differentiation by mechanical cues, we investigated the influence of matrix stiffness (E = 1.46 kPa and E = 26.12 kPa) on differentiated osteogenic cell lineage of bone marrow stem cells (BM-MSCs) and bone-derived cells (BDCs) using flexible collagen-coated...

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PMID: 23447501
DOI: 10.1002/cbin.10078

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