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Article

Neurogranin Regulates Alcohol Sensitivity through AKT Pathway in the Nucleus Accumbens.

Proteomics - 1 Jan 2020

Nam Hyung W, Grant Caleb A, Jorgensen Ashton N, Holtz-Heppelmann Carrie J, Trutschl Marjan, Cvek Urska

Abstract excerpt

Dysfunction of glutamate neurotransmission in the nucleus accumbens (NAc) has been implicated in the pathophysiology of alcohol use disorders (AUD). Neurogranin (Ng) is exclusively expressed in the brain and mediates N-methyl-d-aspartate receptor (NMDAR) hypo-function by regulating the intracellular calcium-calmodulin (Ca2+ -CaM) pathway. Ng null mice (Ng-/- mice) demonstrate increased alcohol drinking compared...

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Identifiers

PMID: 31814311
DOI: 10.1002/pmic.201900266
PMCID: PMC7038789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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