Article

A schizophrenia risk gene, <i>NRGN</i> , bidirectionally modulates synaptic plasticity via regulating the neuronal phosphoproteome

2018-11-29

Abstract excerpt

NRGN is a schizophrenia risk gene identified in recent genetic studies, encoding a small neuronal protein, neurogranin (Ng). Individuals carrying a risk variant of NRGN showed decreased hippocampal activation during contextual fear conditioning. Furthermore, the expression of Ng was reduced in the post-mortem brains of schizophrenic patients. Using the mouse model, we found that the translation of Ng in hippocamp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d00b23ba-8fa3-56b5-86c6-d8b6c048a102
DOI: 10.1101/481291

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A schizophrenia risk gene, <i>NRGN</i> , bidirectionally modulates synaptic plasticity via regulating the neuronal phosphoproteomeDOI 10.1101/481291Read

GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia.Semantic proximity Read

Neuregulin-1 and schizophrenia in the genome-wide association study era.Semantic proximity Read

Dysregulated Expression of Neuregulin-1 by Cortical Pyramidal Neurons Disrupts Synaptic PlasticitySemantic proximity Read

Neuregulin1 nuclear signaling influences adult neurogenesis and regulates a schizophrenia susceptibility gene network within the mouse dentate gyrusSemantic proximity Read

Neuregulin1 Nuclear Signaling Influences Adult Neurogenesis and Regulates a Schizophrenia Susceptibility Gene Network within the Mouse Dentate Gyrus.Semantic proximity Read

Overexpression of Neuregulin 1 Type III Confers Hippocampal mRNA Alterations and Schizophrenia-Like Behaviors in MiceSemantic proximity Read

Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in <i>Grin2a</i> mutant miceSemantic proximity Read

Brain-Specific Deletion of GIT1 Impairs Cognition and Alters Phosphorylation of Synaptic Protein Networks Implicated in Schizophrenia SusceptibilitySemantic proximity Read

NMDA Receptors in Neurodevelopmental Disorders: Pathophysiology and Disease ModelsSemantic proximity Read

Diversification of dentate gyrus granule cell subtypes is regulated by Nrg1 nuclear back-signaling.Semantic proximity Read

Functional Analysis of Human GRIN2A Mutations Associated with Schizophrenia and Neurodevelopmental Disorders Reveals Distinct Pathological MechanismSemantic proximity Read

Changes in neural network homeostasis trigger neuropsychiatric symptoms.Semantic proximity Read