Article
Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence.
The international journal of neuropsychopharmacology - 1 Mar 2014
Toriumi Kazuya, Kondo Mizuki, Nagai Taku, Hashimoto Ryota, Ohi Kazutaka, Song Ziyu, Tanaka Junko, Mouri Akihiro, Koseki Takenao, Yamamori Hidenaga, Furukawa-Hibi Yoko, Mamiya Takayoshi, Fukushima Takeshi, Takeda Masatoshi, Nitta Atsumi, Yamada Kiyofumi, Nabeshima Toshitaka
Abstract excerpt
In a previous report, we identified a novel molecule, SHATI/NAT8L, having an inhibitory effect on methamphetamine (METH)-induced hyperlocomotion, sensitization, and conditioned place preference (CPP). SHATI/NAT8L attenuates the METH-induced increase in dopamine overflow in the nucleus accumbens (NAc) by promoting plasmalemmal and vesicular dopamine uptake. However, the biological functions of the protein remain...
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