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Article

Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Jul 2009

Cozzoli Debra K, Goulding Scott P, Zhang Ping Wu, Xiao Bo, Hu Jia-Hua, Ary Alexis W, Obara Ilona, Rahn Alison, Abou-Ziab Hoda, Tyrrel Burgundy, Marini Christina, Yoneyama Naomi, Metten Pamela, Snelling Christopher, Dehoff Marlin H, Crabbe John C, Finn Deborah A, Klugmann Matthias, Worley Paul F, Szumlinski Karen K

Abstract excerpt

The glutamate receptor-associated protein Homer2 regulates alcohol-induced neuroplasticity within the nucleus accumbens (NAC), but the precise intracellular signaling cascades involved are not known. This study examined the role for NAC metabotropic glutamate receptor (mGluR)-Homer2-phosphatidyli...

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Identifiers

PMID: 19587272
DOI: 10.1523/JNEUROSCI.5900-08.2009
PMCID: PMC2761716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19587272-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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