Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DlgS97/SAP97, a neuronal isoform of discs large, regulates ethanol tolerance.

PloS one - 1 Jan 2012

Maiya Rajani, Lee Seonok, Berger Karen H, Kong Eric C, Slawson Justin B, Griffith Leslie C, Takamiya Kogo, Huganir Richard L, Margolis Ben, Heberlein Ulrike

Abstract excerpt

From a genetic screen for Drosophila melanogaster mutants with altered ethanol tolerance, we identified intolerant (intol), a novel allele of discs large 1 (dlg1). Dlg1 encodes Discs Large 1, a MAGUK (Membrane Associated Guanylate Kinase) family member that is the highly conserved homolog of mammalian PSD-95 and SAP97. The intol mutation disrupted specifically the expression of DlgS97, a SAP97 homolog, and one of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ethanol

Share to Guanylate Kinases

Share to Protein Isoforms

Share to Receptors, N-Methyl-D-Aspartate

Share to Repressor Proteins

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23145041
DOI: 10.1371/journal.pone.0048967
PMCID: PMC3492131

Genes

PSD
CASK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DlgS97/SAP97, a neuronal isoform of discs large, regulates ethanol tolerance.PMID 23145041Read ↗

DLGS97/SAP97 is developmentally upregulated and is required for complex adult behaviors and synapse morphology and function.Semantic proximity Read ↗

Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila.Semantic proximity Read ↗

Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97.Semantic proximity Read ↗

Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene.Semantic proximity Read ↗

Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia.Semantic proximity Read ↗

The Drosophila tumor suppressor gene dlg is required for normal synaptic bouton structure.Semantic proximity Read ↗

Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors.Semantic proximity Read ↗

Perineurial Barrier Glia Physically Respond to Alcohol in an Akap200-Dependent Manner to Promote Tolerance.Semantic proximity Read ↗

Tolerance in Drosophila.Semantic proximity Read ↗

Neurogranin Regulates Alcohol Sensitivity through AKT Pathway in the Nucleus Accumbens.Semantic proximity Read ↗

A Drosophila temperature-sensitive seizure mutant in phosphoglycerate kinase disrupts ATP generation and alters synaptic function.Semantic proximity Read ↗

A role for dynamin in triggering ethanol tolerance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.