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Article

A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.

Gut - 1 Nov 2017

Kim Han Sang, Cheon Jae Hee, Jung Eun Suk, Park Joonhee, Aum Sowon, Park Soo Jung, Eun Sungho, Lee Jinu, Rüther Ulrich, Yeo Giles S H, Ma Marcella, Park Kyong Soo, Naito Takeo, Kakuta Yoichi, Lee Ji Hyun, Kim Won Ho, Lee Min Goo

Abstract excerpt

OBJECTIVE: Myelosuppression is a life-threatening complication of thiopurine therapy, and the incidence of thiopurine-induced myelosuppression is higher in East Asians than in Europeans. We investigated genetic factors associated with thiopurine-induced leukopenia in patients with IBD. DESIGN: A genome-wide association study (GWAS) was conducted in thiopurine-treated patients with IBD, followed by high-throughput...

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Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27558924
DOI: 10.1136/gutjnl-2016-311921

Genes

FTO
RUNX1

Variants

rs16957920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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