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Article

The origin of leukemia: Genetic alterations and inflammatory factors in the development of premalignant clonal hematopoiesis.

Seminars in hematology - 1 Jan 2020

Sjövall Daniel, Staffas Anna

Abstract excerpt

Clonal hematopoiesis of indetermined potential (CHIP) is increasingly common with age and identified in more than 1 in 10 healthy individuals at the age of 70. Mutations in epigenetic and splicing factors are recurrent genetic events in CHIP, and experimental data suggest that microbial and inflammatory factors may contribute to the selective expansion of hematopoietic stem cells carrying these mutations. In...

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PMID: 32690142
DOI: 10.1053/j.seminhematol.2020.05.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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