Article
Somatic inflammatory gene mutations in human ulcerative colitis epithelium.
Nature - 1 Jan 2020
Nanki Kosaku, Fujii Masayuki, Shimokawa Mariko, Matano Mami, Nishikori Shingo, Date Shoichi, Takano Ai, Toshimitsu Kohta, Ohta Yuki, Takahashi Sirirat, Sugimoto Shinya, Ishimaru Kazuhiro, Kawasaki Kenta, Nagai Yoko, Ishii Ryota, Yoshida Kosuke, Sasaki Nobuo, Hibi Toshifumi, Ishihara Soichiro, Kanai Takanori, Sato Toshiro
Abstract excerpt
With ageing, normal human tissues experience an expansion of somatic clones that carry cancer mutations1-7. However, whether such clonal expansion exists in the non-neoplastic intestine remains unknown. Here, using whole-exome sequencing data from 76 clonal human colon organoids, we identify a unique pattern of somatic mutagenesis in the inflamed epithelium of patients with ulcerative colitis. The affected...
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