Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors.

doi:10.1038/s41467-019-13348-2

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors.

Nature communications - 6 Dec 2019

Gusach Anastasiia, Luginina Aleksandra, Marin Egor, Brouillette Rebecca L, Besserer-Offroy Élie, Longpré Jean-Michel, Ishchenko Andrii, Popov Petr, Patel Nilkanth, Fujimoto Taku, Maruyama Toru, Stauch Benjamin, Ergasheva Margarita, Romanovskaia Daria, Stepko Anastasiia, Kovalev Kirill, Shevtsov Mikhail, Gordeliy Valentin, Han Gye Won, Katritch Vsevolod, Borshchevskiy Valentin, Sarret Philippe, Mishin Alexey, Cherezov Vadim

Abstract excerpt

Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-inflammatory responses associated with allergic disorders. While selective inhibition of CysLT1R has been used for treating asthma and associated diseases for over two decades, CysLT2R has recently started to emerge as a potential drug target against atopic asthma, brain injury and central nervous system disorders, as well as several...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

Share to HEK293 Cells

Share to Ligands

Share to Molecular Docking Simulation

Share to Mutagenesis

Share to Protein Engineering

Share to Sf9 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 31811124
DOI: 10.1038/s41467-019-13348-2
PMCID: PMC6897958

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors.PMID 31811124Read ↗

A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma.Semantic proximity Read ↗

Cysteinyl‐leukotrienes and their receptors in asthma and other inflammatory diseases: Critical update and emerging trendsSemantic proximity Read ↗

Functional Characterization of Human Cysteinyl Leukotriene 1 Receptor Gene StructureSemantic proximity Read ↗

The cysteinyl-leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma.Semantic proximity Read ↗

Functional probes of drug-receptor interactions implicated by structural studies: Cys-loop receptors provide a fertile testing ground.Semantic proximity Read ↗

Association between a polymorphism in cysteinyl leukotriene receptor 2 on chromosome 13q14 and atopic asthma.Semantic proximity Read ↗

Structural determinants of ligand response specificity in the mast cell activating GPCR, MRGPRX2.Semantic proximity Read ↗

G-protein-coupled receptors and asthma endophenotypes: the cysteinyl leukotriene system in perspective.Semantic proximity Read ↗

Cysteinyl leukotrienes in allergic inflammation: strategic target for therapy.Semantic proximity Read ↗

A functional G300S variant of the cysteinyl leukotriene 1 receptor is associated with atopy in a Tristan da Cunha isolate.Semantic proximity Read ↗

Structure of a lasso peptide bound ETB receptor provides insights into the mechanism of GPCR inverse agonismSemantic proximity Read ↗

The biochemical, molecular, and genomic aspects of leukotriene C4 synthase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.